Visible-light photoredox intramolecular difluoroacetamidation: facile synthesis of 3,3-difluoro-2-oxindoles from bromodifluoroacetamides.

نویسندگان

  • Xiao-Jing Wei
  • Lin Wang
  • Shao-Fu Du
  • Li-Zhu Wu
  • Qiang Liu
چکیده

We report an operationally simple, visible-light-driven protocol for intramolecular C-H difluoroacetamidation of arenes for the synthesis of biologically relevant 3,3-difluoro-2-oxindoles at room temperature. Using fac-Ir(ppy)3 as a photocatalyst and a 3 W blue LED as a light source, an array of difluoroxindoles was prepared from rapidly available tertiary aryl bromodifluoroacetamides in moderate to excellent yields.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 14 7  شماره 

صفحات  -

تاریخ انتشار 2016